Unraveling the Molecular Players at the Cholinergic Efferent Synapse of the Zebrafish Lateral Line.

ABSTRACT: The lateral line (LL) is a sensory system that allows fish and amphibians to detect water currents. LL responsiveness is modulated by efferent neurons that aid in distinguishing between external and self-generated stimuli, maintaining sensitivity to relevant cues. One component of the efferent system is cholinergic, the activation of which inhibits afferent activity. LL hair cells (HCs) share structural, functional, and molecular similarities with those of the cochlea, making them a popular model for studying human hearing and balance disorders. Because of these commonalities, one could propose that the receptor at the LL efferent synapse is a α9α10 nicotinic acetylcholine receptor (nAChR). However, the identities of the molecular players underlying ACh-mediated inhibition in the LL remain

SUBMITTER: Carpaneto Freixas AE 

PROVIDER: S-EPMC7786207 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature