Oxygen in Red Blood Cell Concentrates: Influence of Donors' Characteristics and Blood Processing.

ABSTRACT: Objective: Unexpectedly wide distribution (<10 to >90%) of hemoglobin oxygen saturation (sO₂) within red cell concentrates (RCCs) has recently been observed. Causes of such variability are not yet completely explained whereas the roles of oxygen and oxidative lesions during the storage of RCCs are known. The objectives of the present study are to characterize sO₂ distribution in RCCs produced in a Swiss blood center and to investigate the influence of processing and donors' characteristics. Methods: The level of sO₂ was measured in 1701 leukocyte-depleted RCCs derived from whole blood donations in both top-bottom (TB; component filtered, SAGM) and top-top (TT; whole blood filtration, PAGGSM) RCCs. The sO₂ value was measured non-inva

SUBMITTER: Bardyn M 

PROVIDER: S-EPMC7786264 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature