The promise of placental extracellular vesicles: models and challenges for diagnosing placental dysfunction in utero†.

ABSTRACT: Monitoring the health of a pregnancy is of utmost importance to both the fetus and the mother. The diagnosis of pregnancy complications typically occurs after the manifestation of symptoms, and limited preventative measures or effective treatments are available. Traditionally, pregnancy health is evaluated by analyzing maternal serum hormone levels, genetic testing, ultrasonographic imaging, and monitoring maternal symptoms. However, researchers have reported a difference in extracellular vesicle (EV) quantity and cargo between healthy and at-risk pregnancies. Thus, placental EVs (PEVs) may help to understand normal and aberrant placental development, monitor pregnancy health in terms of developing placental pathologies, and assess the impact of environmental influences, such as infection,

SUBMITTER: Block LN 

PROVIDER: S-EPMC7786267 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature