Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulatory T Cells to Protect Against Autoimmune Encephalomyelitis.

ABSTRACT: Achieving immunoregulation via in vivo expansion of Foxp3⁺ regulatory CD4⁺ T cells (Treg) remains challenging. We have shown that mobilization confers to multipotent hematopoietic progenitors (MPPs) the capacity to enhance Treg proliferation. Transcriptomic analysis of Tregs co-cultured with MPPs revealed enhanced expression of genes stabilizing the suppressive function of Tregs as well as the activation of IL-1β-driven pathways. Adoptive transfer of only 25,000 MPPs effectively reduced the development of experimental autoimmune encephalomyelitis (EAE), a pre-clinical model for multiple sclerosis (MS). Production of the pathogenic cytokines IL-17 and GM-CSF by spinal cord-derived CD4⁺ T-cells in MPP-protected recipients was reduced while Treg expansi

SUBMITTER: Korniotis S 

PROVIDER: S-EPMC7786289 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature