Use of zebrafish larvae lateral line to study protection against cisplatin-induced ototoxicity: A scoping review.

ABSTRACT:

Aim

The present review aimed to consolidate and analyze the recent information about the use of zebrafish in studies concerning cisplatin-induced ototoxicity and otoprotection.

Material and methods

The PubMed, Web of Science, and Scopus databanks were searched using the following MESH terms: zebrafish, cisplatin, ototoxicity. The identified publications were screened according to inclusion and exclusion criteria and the 26 qualifying manuscripts were included in the full-text analysis. The experimental protocols, including cisplatin concentrations, the exposure duration and the outcome measurements used in zebrafish larvae studies, were evaluated and the reported knowledge was summarized.

Results

Twenty-six substances protecting from cisplatin-induced toxicity were id

SUBMITTER: Domarecka E 

PROVIDER: S-EPMC7786420 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature