D-mannose ameliorates autoimmune phenotypes in mouse models of lupus.

ABSTRACT:

Background

Systemic lupus erythematosus is an autoimmune disease characterized by an overproduction of autoantibodies resulting from dysregulation in multiple immune cell types. D-mannose is a C^- 2 epimer of glucose that exhibits immunoregulatory effects in models of autoimmune diseases, such as type 1 diabetes, induced rheumatoid arthritis, and airway inflammation. This study was conducted to evaluate the efficacy of D-mannose treatment in mouse models of lupus.

Results

Firstly, the effect of D-Mannose was evaluated by flow cytometry on the in vitro activation of non-autoimmune C57BL/6 (B6) bone marrow-derived dendritic cells (BMDCs) and their ability to induce antigen-specific CD4⁺ T cell proliferation and activation. D-mannose inhibited the maturatio

SUBMITTER: Wang H 

PROVIDER: S-EPMC7786459 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature