Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson's disease model.

ABSTRACT:

Background

Cognitive decline occurs frequently in Parkinson's disease (PD), which greatly decreases the quality of life of patients. However, the mechanisms remain to be investigated. Neuroinflammation mediated by overactivated microglia is a common pathological feature in multiple neurological disorders, including PD. This study is designed to explore the role of microglia in cognitive deficits by using a rotenone-induced mouse PD model.

Methods

To evaluate the role of microglia in rotenone-induced cognitive deficits, PLX3397, an inhibitor of colony-stimulating factor 1 receptor, and minocycline, a widely used antibiotic, were used to deplete or inactivate microglia, respectively. Cognitive performance of mice among groups was detected by Morris water maze, objective recogn

SUBMITTER: Zhang D 

PROVIDER: S-EPMC7786472 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature