Association of calprotectin with other inflammatory parameters in the prediction of mortality for ischemic stroke.

ABSTRACT:

Background

Inflammatory response plays an important role in many processes related to acute ischemic stroke (AIS). Calprotectin (S100A8/S100A9), released by monocytes and neutrophils, is a key protein in the regulation of inflammation and thrombosis. The purpose of this study is to evaluate the association of circulating calprotectin with other inflammatory biomarkers and AIS prognosis, as well as the calprotectin content in stroke thrombi.

Methods

Among the 748 patients treated at a comprehensive stroke center between 2015 and 2017, 413 patients with confirmed acute ischemic injury were prospectively evaluated. Patients with systemic inflammation or infection at onset were excluded. Plasma calprotectin was measured by ELISA in blood samples of AIS patients within the first

SUBMITTER: Marta-Enguita J 

PROVIDER: S-EPMC7786493 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature