Green sonochemical synthesis and fabrication of cubic MnFe₂O₄ electrocatalyst decorated carbon nitride nanohybrid for neurotransmitter detection in serum samples.

ABSTRACT: The binary nanomaterials and graphitic carbon based hybrid has been developed as an important porous nanomaterial for fabricating electrode with applications in non-enzymatic (bio) sensors. We report a fast synthesis of bimetal oxide particles of nano-sized manganese ferrite (MnFe₂O₄) decorated on graphitic carbon nitride (GCN) via a high-intensity ultrasonic irradiation method for C (30 kHz and 70 W/cm²). The nanocomposites were analyzed by powder X-ray diffraction, XPS, EDS, TEM to ascertain the effects of synthesis parameters on structure, and morphology. The MnFe₂O₄/GCN modified electrode demonstrated superior electrocatalytic activity toward the neurotransmitter (5-hydroxytryptamine) detection with a high peak intensity at +0.21 V. The appealing application of the MnFe₂O₄/GCN/GCE as neurotransmitter sensors is presented and a possible sensing mechanism is analyzed. The constructed electrochemical sensor for the detection of 5-hydroxytryptamine (STN) showed a wide working range (0.1-522.6 ?M), high sensitivity (19.377 ?A ?M^-1 cm^-2), and nano-molar detection limit (3.1 nM). Moreover, it is worth noting that the MnFe₂O₄/GCN not only enhanced activity and also promoted the electron transfer rate towards STN detection. The proposed sensor was analyzed for its real-time applications to the detection of STN in rat brain serum, and human blood serum in good satisfactory results was obtained. The results showed promising reproducibility, repeatability, and high stability for neurotransmitter detection in biological samples.

SUBMITTER: Elshikh MS 

PROVIDER: S-EPMC7786591 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature