Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity.

ABSTRACT: Gamma activity arising from the interplay between pyramidal neurons and fast-spiking parvalbumin (PV) interneurons is an integral part of higher cognitive functions and is assumed to contribute significantly to brain metabolic responses. Cerebral metabolic rate of oxygen (CMRO₂) responses were evoked by optogenetic stimulation of cortical PV interneurons and pyramidal neurons. We found that CMRO₂ responses depended on neuronal activation, but not on the power of gamma activity induced by optogenetic stimulation. This implies that evoked gamma activity per se is not energy demanding. Optogenetic stimulation of PV interneurons during somatosensory stimulation reduced excitatory neuronal activity but did not potentiate O₂ consumption as previously hypothesized

SUBMITTER: Dahlqvist MK 

PROVIDER: S-EPMC7786843 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature