N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease.

ABSTRACT:

Background

N6-methyladenosine (m⁶A) modification is known to impact many aspects of RNA metabolism, including mRNA stability and translation, and is highly prevalent in the brain.

Results

We show that m⁶A modification displays temporal and spatial dynamics during neurodevelopment and aging. Genes that are temporally differentially methylated are more prone to have mRNA expression changes and affect many pathways associated with nervous system development. Furthermore, m⁶A shows a distinct tissue-specific methylation profile, which is most pronounced in the hypothalamus. Tissue-specific methylation is associated with an increase in mRNA expression and is associated with tissue-specific developmental processes. During the aging process, we obse

SUBMITTER: Shafik AM 

PROVIDER: S-EPMC7786910 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature