Association of Aβ deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [¹¹C]UCB-J.

ABSTRACT:

Background

Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer's disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ plaque burden is not well-correlated with indices of clinical severity or neurodegeneration-at least in the dementia stage-as deposition of Aβ reaches a ceiling. In this study, we examined in vivo the association between fibrillar Aβ deposition and synaptic density in early AD using positron emission tomography (PET). We hypothesized that global Aβ deposition would be more strongly inversely associated with hippocampal synaptic density in participants with amnestic mild cognitive impairment (aMCI; a stage of continued Aβ accumulation) compared to those with dementia (a stage of relative Aβ plateau).

Meth

SUBMITTER: O'Dell RS 

PROVIDER: S-EPMC7786921 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature