Analysis of pain markers and epidural fibrosis caused by repeated spinal surgery in Sprague-Dawley rats.

ABSTRACT:

Background

Epidural fibrosis is one of the aetiologies of pain following a spinal revision surgery. It is reported that the specific members of the mitogen - activated protein kinases (MAPK) family might mediate neuropathic pain. However, roles of epidural fibrosis caused by repeated spinal surgeries and pain-related proteins in causing the post spinal surgery syndrome remain unknown. Using a rat spinal surgery epidural fibrosis and adhesion model, in this study, we evaluated and investigated the relationship between pain markers and epidural fibrosis.

Methods

Sprague-Dawley rats that underwent the spinal surgery were divided into three groups: group A (single laminectomy), group B (two repeated surgeries) and group C (three repeated surgeries). Dural thickness was measured

SUBMITTER: Quan M 

PROVIDER: S-EPMC7786924 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature