Does surfactant nebulization prevent early intubation in preterm infants? A protocol for a systematic review and meta-analysis.

ABSTRACT:

Background

Respiratory distress syndrome (RDS) is the most common cause of respiratory failure in preterm infants. Treatment consists of respiratory support and exogenous surfactant administration. Commonly, surfactant is administered intratracheally. However, this requires airway instrumentation and subsequent fluid instillation which may be harmful. Surfactant nebulization (SN) may offer a safe and effective alternative for surfactant administration, but the clinical efficacy is not yet established. Thus, this systematic review and meta-analysis of randomized controlled trials will summarize the available evidence to determine the effectiveness and safety of SN for the prevention of intubation and subsequent mechanical ventilation at 72 h after birth.

Methods

A systematic

SUBMITTER: Gaertner VD 

PROVIDER: S-EPMC7786931 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature