The insulin resistance by triglyceride glucose index and risk for dementia: population-based study.

ABSTRACT:

Background

Insulin resistance is suggested to have negative effects on cognition; however, results from large population studies are lacking. In this study, the potential relationships between the triglyceride glucose (TyG) index, a simple surrogate marker of insulin resistance, and dementia were evaluated using a large-scale population dataset.

Methods

This was a retrospective, observational, cohort study using data from the National Health Information Database from 2009 to 2015 and included 5,586,048 participants 40 years age or older. The TyG index was used as a measure of insulin resistance, and participants were divided into quartiles based on TyG index. The incidence of dementia was assessed using hazard ratios (HRs) estimated with Cox proportional hazard modeling.

SUBMITTER: Hong S 

PROVIDER: S-EPMC7786939 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature