Distinct network topology in Alzheimer's disease and behavioral variant frontotemporal dementia.

ABSTRACT:

Background

Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) cause distinct atrophy and functional disruptions within two major intrinsic brain networks, namely the default network and the salience network, respectively. It remains unclear if inter-network relationships and whole-brain network topology are also altered and underpin cognitive and social-emotional functional deficits.

Methods

In total, 111 participants (50 AD, 14 bvFTD, and 47 age- and gender-matched healthy controls) underwent resting-state functional magnetic resonance imaging (fMRI) and neuropsychological assessments. Functional connectivity was derived among 144 brain regions of interest. Graph theoretical analysis was applied to characterize network integration, segregation,

SUBMITTER: Ng ASL 

PROVIDER: S-EPMC7786961 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature