CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy.

ABSTRACT:

Background

Serum tumor markers including AFU, AFP, CEA, CA199, CA125 and CA724, are of great importance in the diagnosis, prognostic prediction and recurrence monitoring of gastrointestinal malignancies. However, their significance in gastric cancer (GC) patients with neoadjuvant therapy (NCT) is still uncertain. The aim of this study was to evaluate the predictive value of these six tumor markers in locally advanced GC patients who underwent NCT and curative surgery.

Methods

In total, 290 locally advanced GC patients who underwent NCT and D2 radical gastrectomy were retrospectively analyzed. Data on their tumor markers before (pre-) and after (post-) NCT and pathological characteristics were extracted from the database of our hospital. The optimal cutoff values of the six t

SUBMITTER: Tong Y 

PROVIDER: S-EPMC7786973 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature