Genetic susceptibility of opioid receptor genes polymorphism to drug addiction: A candidate-gene association study.

ABSTRACT:

Background

Like other complex diseases including drug addiction, genetic factors can interfere with the disease. In this study, three opioid genes (OPRM1, OPRD1, and OPRK1) were examined for an association with drug addiction among Jordanian males.

Methods

The study involved 498 addicts, in addition to 496 healthy controls and all from Arab descent.

Results

The findings in this study showed that rs1799971 of the OPRM1 gene was in association with drug addiction for both alleles and genotypes with P-values = 0.002 and 0.01, respectively. In addition, a significant association between the dominant model (A/A vs G/A-G/G) of rs1799971 (OPRM1) and drug addiction (P-value = 0.003, OR = 1.59 (1.17-2.15)) was detected. Moreover, a genetic haplotype (AGGGCGACCCC) of theOPRM1 g

SUBMITTER: Al-Eitan LN 

PROVIDER: S-EPMC7786995 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature