Germacrone alleviates neurological deficits following traumatic brain injury by modulating neuroinflammation and oxidative stress.

ABSTRACT:

Background

Germacrone (GM) is a terpenoid compound which is reported to have anti-inflammatory and anti-oxidative effects. However, its role in treating traumatic brain injury (TBI) remains largely unknown.

Methods

Male C57BL/6 mice were divided into the following groups: control group, TBI group [controlled cortical impact (CCI) model], CCI + 5 mg/kg GM group, CCI + 10 mg/kg GM group and CCI + 20 mg/kg GM group. GM was administered via intraperitoneal injection. The neurological functions (including motor coordination, spatial learning and memory abilities) and brain edema were measured. Nissl staining was used to detect the neuronal apoptosis. Colorimetric assays and enzyme linked immunosorbent assay (ELISA) kits were used to determine the expression levels of oxidative st

SUBMITTER: Zhuang S 

PROVIDER: S-EPMC7786997 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature