Mechanics of a multilayer epithelium instruct tumour architecture and function.

ABSTRACT: Loss of normal tissue architecture is a hallmark of oncogenic transformation¹. In developing organisms, tissues architectures are sculpted by mechanical forces during morphogenesis². However, the origins and consequences of tissue architecture during tumorigenesis remain elusive. In skin, premalignant basal cell carcinomas form 'buds', while invasive squamous cell carcinomas initiate as 'folds'. Here, using computational modelling, genetic manipulations and biophysical measurements, we identify the biophysical underpinnings and biological consequences of these tumour architectures. Cell proliferation and actomyosin contractility dominate tissue architectures in monolayer, but not multilayer, epithelia. In stratified epidermis, meanwhile, softening and enhanced remodel

SUBMITTER: Fiore VF 

PROVIDER: S-EPMC7787055 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature