CERES: a cryo-EM re-refinement system for continuous improvement of deposited models.

ABSTRACT: The field of electron cryomicroscopy (cryo-EM) has advanced quickly in recent years as the result of numerous technological and methodological developments. This has led to an increase in the number of atomic structures determined using this method. Recently, several tools for the analysis of cryo-EM data and models have been developed within the Phenix software package, such as phenix.real_space_refine for the refinement of atomic models against real-space maps. Also, new validation metrics have been developed for low-resolution cryo-EM models. To understand the quality of deposited cryo-EM structures and how they might be improved, models deposited in the Protein Data Bank that have map resolutions of better than 5 Å were automatically re-refined using current versions of Phenix tools. T

SUBMITTER: Liebschner D 

PROVIDER: S-EPMC7787109 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature