Dendritic cell responses to Plasmodium falciparum in a malaria-endemic setting.

ABSTRACT:

Background

Plasmodium falciparum causes the majority of malaria cases worldwide and children in sub-Saharan Africa are the most vulnerable group affected. Non-sterile clinical immunity that protects from symptoms develops slowly and is relatively short-lived. Moreover, current malaria vaccine candidates fail to induce durable high-level protection in endemic settings, possibly due to the immunomodulatory effects of the malaria parasite itself. Because dendritic cells play a crucial role in initiating immune responses, the aim of this study was to better understand the impact of cumulative malaria exposure as well as concurrent P. falciparum infection on dendritic cell phenotype and function.

Methods

In this cross-sectional study, the phenotype and function of dendritic cells

SUBMITTER: Turner TC 

PROVIDER: S-EPMC7787131 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature