Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene.

ABSTRACT:

Impact statement

Mitochondria are dynamic organelles undergoing fission and fusion. Proper regulation of this process is important for healthy aging process, as aberrant mitochondrial dynamics are associated with several age-related diseases/pathologies. However, it is not well understood how imbalanced mitochondrial dynamics may lead to those diseases and pathologies. Here, we aimed to determine metabolic alterations in tissues and cells from mouse models with over-fused (fusion > fission) and over-fragmented (fusion < fission) mitochondria that display age-related disease pathologies. Our results indicated tissue-dependent sensitivity to these mitochondrial changes, and metabolic pathways likely affected by aberrant mitochondrial dynamics. This study provides new insights into ho

SUBMITTER: Lee WH 

PROVIDER: S-EPMC7787545 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature