Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice.

ABSTRACT:

Impact statement

Despite increasing evidence implicating the important role of TDP-43 in the pathogenesis of a wide range of age-related neurodegenerative diseases, there is limited study of TDP-43 proteinopathy and its association with mitochondria during normal aging. Our findings of cytoplasmic accumulation of TDP-43 that is highly colocalized with mitochondria in neurons in selective brain regions in young animals in the absence of neuronal loss provide a novel insight into the development of TDP-43 proteinopathy and its contribution to neuronal loss.

SUBMITTER: Termsarasab P 

PROVIDER: S-EPMC7787547 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature