MiRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy.

ABSTRACT: Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory dilated cardiomyopathy caused by lifelong infection with the protozoan Trypanosoma cruzi, is a major cause of cardiomyopathy in Latin America. Although chronic myocarditis may play a major pathogenetic role, little is known about the molecular mechanisms responsible for its severity. The aim of this study is to study the genes and microRNAs expression in tissues and their connections in regards to the pathobiological processes. To do so, we integrated for the first time global microRNA and mRNA expression profiling from myocardial tissue of CCC patients employing pathways and network analyses. We observed an enrichment in biological processes and pathways associated with the immune response and metabolism. I

SUBMITTER: Laugier L 

PROVIDER: S-EPMC7787679 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature