Functional Correlates of Action Observation of Gait in Patients with Parkinson's Disease.

ABSTRACT:

Background

Action observation (AO) relies on the mirror neuron system (MNS) and has been proposed as a rehabilitation tool in Parkinson's disease (PD), in particular for gait disorder such as freezing of gait (FOG). In this study, we aimed to explore the brain functional correlates of the observation of human gait in PD patients with (FOG+) and without (FOG-) FOG and to investigate a possible relationship between AO-induced brain activation and gait performance.

Methods

Fifty-four participants were enrolled in the study (15 PD FOG+; 18 PD FOG-; 21 healthy subjects (HS)) which consisted of two tasks in two separate days: (i) gait assessment and (ii) task-fMRI during AO of gait. Differences between patients with PD (FOG+ and FOG-) and HS were assessed at the level of behaviora

SUBMITTER: Bommarito G 

PROVIDER: S-EPMC7787806 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature