A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks.

ABSTRACT: The vascular network of the circulatory system plays a vital role in maintaining homeostasis in the human body. In this paper, a novel modular microfluidic system with a vertical two-layered configuration is developed to generate large-scale perfused microvascular networks in vitro. The two-layer polydimethylsiloxane (PDMS) configuration allows the tissue chambers and medium channels not only to be designed and fabricated independently but also to be aligned and bonded accordingly. This method can produce a modular microfluidic system that has high flexibility and scalability to design an integrated platform with multiple perfused vascularized tissues with high densities. The medium channel was designed with a rhombic shape and fabricated to be semiclosed to form a capillary burst valve in

SUBMITTER: Yue T 

PROVIDER: S-EPMC7787972 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature