Ectonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function.

ABSTRACT: Adult T-cell leukemia/lymphoma (ATLL) patients have an extremely poor prognosis, partly due to their immunosuppressive state. The majority of ATLL patients have leukemic cells with phenotype similar to Tregs, prompting suggestions that ATLL cells themselves have immunosuppressive functions. In this study, we detected CD39 expression on ATLL cells, particularly frequent on aggressive subtypes. CD39 and CD73 convert extracellular adenosine triphosphate (ATP) into adenosine, a key player in Tregs' immunosuppression. In vitro culture, both CD39⁺ ATLL cells and normal Tregs converted rapidly extracellular ATP to AMP, which was disturbed by CD39 inhibitors, and was negated in the CD39 knockout MJ cell line. The proliferation of cocultured CD4⁺/CD8⁺ normal T cells

SUBMITTER: Nagate Y 

PROVIDER: S-EPMC7787980 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature