New insights on key genes involved in drought stress response of barley: gene networks reconstruction, hub, and promoter analysis.

ABSTRACT:

Background

Barley (Hordeum vulgare L.) is one of the most important cereals worldwide. Although this crop is drought-tolerant, water deficiency negatively affects its growth and production. To detect key genes involved in drought tolerance in barley, a reconstruction of the related gene network and discovery of the hub genes would help. Here, drought-responsive genes in barley were collected through analysis of the available microarray datasets (- 5 ≥ Fold change ≥ 5, adjusted p value ≤ 0.05). Protein-protein interaction (PPI) networks were reconstructed.

Results

The hub genes were identified by Cytoscape software using three Cyto-hubba algorithms (Degree, Closeness, and MNC), leading to the identification of 17 and 16 non-redundant genes at vegetative and reproductive stage

SUBMITTER: Javadi SM 

PROVIDER: S-EPMC7788114 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature