Structure and intermolecular interactions in spheroidal high-density lipoprotein subpopulations.

ABSTRACT: Human serum high-density lipoproteins (HDLs) are a population of small, dense protein-lipid aggregates that are crucial for intravascular lipid trafficking and are protective against cardiovascular disease. The spheroidal HDL subfraction can be separated by size and density into five major subpopulations with distinct molecular compositions and unique biological functionalities: HDL_3c, HDL_3b, HDL_3a, HDL_2a and HDL_2b. Representative molecular models of these five subpopulations were developed and characterised for the first time in the presence of multiple copies of its primary protein component apolipoprotein A-I (apoA-I) using coarse-grained molecular dynamics simulations. Each HDL model exhibited size, morphological and compositional

SUBMITTER: Malajczuk CJ 

PROVIDER: S-EPMC7788233 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature