Ontology highlight
ABSTRACT:
SUBMITTER: van den Berk P
PROVIDER: S-EPMC7788286 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Cell reports 20201201 13
Altering ubiquitination by disruption of deubiquitinating enzymes (DUBs) affects hematopoietic stem cell (HSC) maintenance. However, comprehensive knowledge of DUB function during hematopoiesis in vivo is lacking. Here, we systematically inactivate DUBs in mouse hematopoietic progenitors using in vivo small hairpin RNA (shRNA) screens. We find that multiple DUBs may be individually required for hematopoiesis and identify ubiquitin-specific protease 15 (USP15) as essential for HSC maintenance in ...[more]