Genetic Survey of Adult-Onset Idiopathic Intracranial Hypertension.

ABSTRACT:

Background

Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure of unknown cause. IIH has been shown to be associated with female sex as well as obesity. This genome-wide association study was performed to determine whether genetic variants are associated with this condition.

Methods

We analyzed the chromosomal DNA of 95 patients with IIH enrolled in the Idiopathic Intracranial Hypertension Treatment Trial and 95 controls matched on sex, body mass index, and self-reported ethnicity. The samples were genotyped using Illumina Infinium HumanCoreExome v1-0 array and analyzed using a generalized linear mixed model that accounted for population stratification using multidimensional scaling.

Results

A total of 301,908 sin

SUBMITTER: Kuehn MH 

PROVIDER: S-EPMC7788379 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature