Nanocomposite Hydrogel with Tantalum Microparticles for Rapid Endovascular Hemostasis.

ABSTRACT: Endovascular embolization to treat vascular hemorrhage involves pushing coil-shaped metal wires into the artery repeatedly until they are densely packed to slow the blood flow and clot. However, coil embolization is associated with high rebleeding rates, unpredictable economics and, most importantly, they rely on the patient's ability to make a clot. These issues are exacerbated when the patient is anticoagulated or coagulopathic. A novel bioengineered tantalum-loaded nanocomposite hydrogel for gel embolic material (Ta-GEM) that can be rapidly delivered using clinical catheters for instant hemostasis regardless of the coagulopathic state is reported. Ta-GEM formulation is visible by most of the clinically available imaging modalities including ultrasound, computed tomography, magnetic reso

SUBMITTER: Albadawi H 

PROVIDER: S-EPMC7788497 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature