AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment.

ABSTRACT: Neurodevelopment is characterized by rapid rates of neural cell proliferation and differentiation followed by massive cell death in which more than half of all recently generated brain cells are pruned back. Large amounts of DNA damage, cellular debris, and by-products of cellular stress are generated during these neurodevelopmental events, all of which can potentially activate immune signalling. How the immune response to this collateral damage influences brain maturation and function remains unknown. Here we show that the AIM2 inflammasome contributes to normal brain development and that disruption of this immune sensor of genotoxic stress leads to behavioural abnormalities. During infection, activation of the AIM2 inflammasome in response to double-stranded DNA damage triggers the produ

SUBMITTER: Lammert CR 

PROVIDER: S-EPMC7788527 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature