Ultraprotective ventilation allowed by extracorporeal CO₂ removal improves the right ventricular function in acute respiratory distress syndrome patients: a quasi-experimental pilot study.

ABSTRACT:

Background

Right ventricular (RV) failure is a common complication in moderate-to-severe acute respiratory distress syndrome (ARDS). RV failure is exacerbated by hypercapnic acidosis and overdistension induced by mechanical ventilation. Veno-venous extracorporeal CO₂ removal (ECCO₂R) might allow ultraprotective ventilation with lower tidal volume (V_T) and plateau pressure (P_plat). This study investigated whether ECCO₂R therapy could affect RV function.

Methods

This was a quasi-experimental prospective observational pilot study performed in a French medical ICU. Patients with moderate-to-severe ARDS with PaO₂/FiO₂ ratio between 80 and 150 mmHg were enrolled. An ultraprotective ventilation strategy wa

SUBMITTER: Goursaud S 

PROVIDER: S-EPMC7788545 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature