Pharmacokinetic Modeling of (R)-[¹¹C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates.

ABSTRACT: (R)-[¹¹C]verapamil is a radiotracer widely used for the evaluation of the P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Several studies have evaluated the pharmacokinetics of (R)-[¹¹C]verapamil in rats and humans under different conditions. However, to the best of our knowledge, the pharmacokinetics of (R)-[¹¹C]verapamil have not yet been evaluated in nonhuman primates. Our study aims to establish (R)-[¹¹C]verapamil as a reference P-gp tracer for comparison of a newly developed P-gp positron emission tomography (PET) tracer in a species close to humans. Therefore, the study assesses the kinetics of (R)-[¹¹C]verapamil and evaluates the effect of scan duration and P-gp inhibition on e

SUBMITTER: Garcia-Varela L 

PROVIDER: S-EPMC7788571 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature