Associations between sensory processing and electrophysiological and neurochemical measures in children with ASD: an EEG-MRS study.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is associated with hyper- and/or hypo-sensitivity to sensory input. Spontaneous alpha power, which plays an important role in shaping responsivity to sensory information, is reduced across the lifespan in individuals with ASD. Furthermore, an excitatory/inhibitory imbalance has also been linked to sensory dysfunction in ASD and has been hypothesized to underlie atypical patterns of spontaneous brain activity. The present study examined whether resting-state alpha power differed in children with ASD as compared to TD children, and investigated the relationships between alpha levels, concentrations of excitatory and inhibitory neurotransmitters, and atypical sensory processing in ASD.

Methods

Participants included thirty-one children a

SUBMITTER: Pierce S 

PROVIDER: S-EPMC7788714 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature