Bioinformatics analysis of common key genes and pathways of intracranial, abdominal, and thoracic aneurysms.

ABSTRACT:

Background

Aneurysm is a severe and fatal disease. This study aims to comprehensively identify the highly conservative co-expression modules and hub genes in the abdominal aortic aneurysm (AAA), thoracic aortic aneurysm (TAA) and intracranial aneurysm (ICA) and facilitate the discovery of pathogenesis for aneurysm.

Methods

GSE57691, GSE122897, and GSE5180 microarray datasets were downloaded from the Gene Expression Omnibus database. We selected highly conservative modules using weighted gene co‑expression network analysis before performing the Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway and Reactome enrichment analysis. The protein-protein interaction (PPI) network and the miRNA-hub genes network were constructed. Furtherly, we validated the preservation o

SUBMITTER: Bi S 

PROVIDER: S-EPMC7788746 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature