Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity.

ABSTRACT:

Background

The establishment of uterine receptivity is essential for embryo implantation initiation and involves a significant morphological transformation in the endometrial epithelial cells (EECs). The remodeling of junctional complexes and membrane-associated cytoskeleton is crucial for epithelial transformation. However, little is known about how this process is regulated in EECs during the receptive phase. ARHGAP19 is a Rho GTPase-activating protein that participates in various cytoskeletal-related events, including epithelial morphogenesis. Here, we investigated the role of ARHGAP19 in endometrial epithelial transformation during the establishment of uterine receptivity. The upstream regulator of ARHGAP19 was also investigated.

Methods

ARHGAP19 expression was examined

SUBMITTER: Liang J 

PROVIDER: S-EPMC7788769 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature