Association of telomere length and telomerase methylation with n-3 fatty acids in preschool children with obesity.

ABSTRACT:

Background

Telomeres play a crucial role in cellular survival and its length is a predictor for onset of chronic non-communicable diseases. Studies on association between telomeres and obesity in children have brought discrepant results and the underlying mechanisms and influential factors are to be elucidated. This study aimed to investigate changes in telomere length and telomerase reverse transcriptase (TERT) DNA methylation, and further to determine their correlation with n-3 polyunsaturated fatty acids (PUFAs) in preschool children with obesity.

Methods

Forty-six preschool children with obesity aged 3 to 4 years were included in the study, with equal numbers of age- and gender-matched children with normal weight as control. Leukocyte telomere length was determined by th

SUBMITTER: Liu X 

PROVIDER: S-EPMC7788823 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature