Characterization of traumatized muscle-derived multipotent progenitor cells from low-energy trauma.

ABSTRACT:

Background

Multipotent progenitor cells have been harvested from different human tissues, including the bone marrow, adipose tissue, and umbilical cord blood. Previously, we identified a population of mesenchymal progenitor cells (MPCs) isolated from the traumatized muscle of patients undergoing reconstructive surgery following a war-related blast injury. These cells demonstrated the ability to differentiate into multiple mesenchymal lineages. While distal radius fractures from a civilian setting have a much lower injury mechanism (low-energy trauma), we hypothesized that debrided traumatized muscle near the fracture site would contain multipotent progenitor cells with the ability to differentiate and regenerate the injured tissue.

Methods

The traumatized muscle was debrided

SUBMITTER: Dingle M 

PROVIDER: S-EPMC7788846 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature