An analytical method for the identification of cell type-specific disease gene modules.

ABSTRACT:

Background

Genome-wide association studies have identified genetic variants associated with the risk of brain-related diseases, such as neurological and psychiatric disorders, while the causal variants and the specific vulnerable cell types are often needed to be studied. Many disease-associated genes are expressed in multiple cell types of human brains, while the pathologic variants affect primarily specific cell types. We hypothesize a model in which what determines the manifestation of a disease in a cell type is the presence of disease module comprised of disease-associated genes, instead of individual genes. Therefore, it is essential to identify the presence/absence of disease gene modules in cells.

Methods

To characterize the cell type-specificity of brain-related dis

SUBMITTER: Guan J 

PROVIDER: S-EPMC7788893 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature