Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates.

ABSTRACT:

Background

Sepsis is a major health issue in preterm infants. Biomarkers are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The aim of this study was to evaluate the association of interleukin-6(IL-6), procalcitonin (PCT) and CRP with subsequent sepsis severity and mortality in preterm infants suspected of late onset neonatal sepsis.

Methods

The study was conducted at the Erasmus University Medical Center-Sophia Children's Hospital Rotterdam. Patient data from January 2018 until October 2019 were reviewed for all preterm neonates born with a gestational age below 32 weeks with signs and symptoms suggestive of systemic infection, in whom blood was taken for blood

SUBMITTER: Kurul S 

PROVIDER: S-EPMC7788923 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature