Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes.

ABSTRACT:

Research question

There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristics as well as outcomes of patients with severe physiologic impairment.

Patients and methods

IPF patients with severe physiologic impairment defined by FVC ≤ 50% and/or DLco ≤ 30% predicted evaluated in the Inova Advanced Lung Disease Program between 2011 and 2019 were included. Demographic, physiologic, functional treatment and outcome data were collated.

Results

There were 531 patients with IPF evaluated of whom 242 (46%) had severe physiologic impairment. Mean age was 72 ± 8 years; baseline FVC was 53 ± 17% and DL_CO 28 ± 

SUBMITTER: Pastre J 

PROVIDER: S-EPMC7788925 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature