Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test.

ABSTRACT:

Background

In order to explore the pathophysiology underlying type 2 diabetes we examined the impact of gene variants associated with type 2 diabetes on circulating levels of glucagon during an oral glucose tolerance test (OGTT). Furthermore, we performed a genome-wide association study (GWAS) aiming to identify novel genomic loci affecting plasma glucagon levels.

Methods

Plasma levels of glucagon were examined in samples obtained at three time points during an OGTT; 0, 30 and 120 min, in two separate cohorts with a total of up to 1899 individuals. Cross-sectional analyses were performed separately in the two cohorts and the results were combined in a meta-analysis.

Results

A known type 2 diabetes variant in EYA2 was significantly associated with higher plasma glucago

SUBMITTER: Jonsson A 

PROVIDER: S-EPMC7788944 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature