Metabolomic signatures of the long-term exposure to air pollution and temperature.

ABSTRACT:

Background

Long-term exposures to air pollution has been reported to be associated with inflammation and oxidative stress. However, the underlying metabolic mechanisms remain poorly understood.

Objectives

We aimed to determine the changes in the blood metabolome and thus the metabolic pathways associated with long-term exposure to outdoor air pollution and ambient temperature.

Methods

We quantified metabolites using mass-spectrometry based global untargeted metabolomic profiling of plasma samples among men from the Normative Aging Study (NAS). We estimated the association between long-term exposure to PM_2.5, NO₂, O₃, and temperature (annual average of central site monitors) with metabolites and their associated metabolic pathways. We u

SUBMITTER: Nassan FL 

PROVIDER: S-EPMC7788989 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature