Genomic profile of metastatic breast cancer patient-derived xenografts established using percutaneous biopsy.

ABSTRACT:

Background

Metastatic breast cancer (mBC) is a complex and life-threatening disease and although it is difficult to cure, patients can benefit from sequential anticancer treatment, including endocrine therapy, targeted therapy and cytotoxic chemotherapy. The patient-derived xenograft (PDX) model is suggested as a practical tool to predict the clinical outcome of this disease as well as to screen novel drugs. This study aimed to establish PDX models in Korean patients and analyze their genomic profiles and utility for translational research.

Methods

Percutaneous core needle biopsy or punch biopsy samples were used for xenotransplantation. Whole exome sequencing and transcriptome analysis were performed to assess the genomic and RNA expression profiles, respectively. Copy numb

SUBMITTER: Kim S 

PROVIDER: S-EPMC7789010 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature