Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.

ABSTRACT:

Background

Abnormalities in lymphocyte surface markers and functions have been described in systemic sclerosis (SSc), but conflicting results abound, and these studies often examined patients with heterogeneous disease duration, severity, clinical phenotype, and concurrent immunosuppressive agents. We studied a clinically homogeneous group of early diffuse cutaneous SSc patients not exposed to immunosuppressive drugs who were enrolled in a clinical trial and compared their immune parameters to healthy control subjects.

Methods

Lymphocyte subsets were enumerated by multi-parameter flow cytometry of peripheral blood mononuclear cells at baseline visit. Production of the cytokines IL-4 and IL-17 was measured by intracellular flow cytometry following T cell activation.

Result

SUBMITTER: Fox DA 

PROVIDER: S-EPMC7789011 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature