Effect of metformin on stem cells: Molecular mechanism and clinical prospect.

ABSTRACT: Metformin is a first-line medication for type II diabetes. Numerous studies have shown that metformin not only has hypoglycemic effects, but also modulates many physiological and pathological processes ranging from aging and cancer to fracture healing. During these different physiological activities and pathological changes, stem cells usually play a core role. Thus, many studies have investigated the effects of metformin on stem cells. Metformin affects cell differentiation and has promising applications in stem cell medicine. It exerts anti-aging effects and can be applied to gerontology and regenerative medicine. The potential anti-cancer stem cell effect of metformin indicates that it can be an adjuvant therapy for cancers. Furthermore, metformin has beneficial effects against many oth

SUBMITTER: Jiang LL 

PROVIDER: S-EPMC7789120 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature