Identification of critical pathways and potential therapeutic targets in poorly differentiated duodenal papilla adenocarcinoma.

ABSTRACT:

Background

Duodenal papilla carcinoma (DPC) is a rare malignancy of the gastrointestinal tract with high recurrence rate, and the pathogenesis of this highly malignant neoplasm is yet to be fully elucidated. This study aims to identify key genes to further understand the biology and pathogenesis underlying the molecular alterations driving DPC, which could be potential diagnostic or therapeutic targets.

Methods

Tumor samples of three DPC patients were collected and integrating RNA-seq analysis of tumor tissues and matched normal tissues were performed to discover differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were carried out to understand the potential bio-functions of the DPC differentially e

SUBMITTER: Lu Y 

PROVIDER: S-EPMC7789135 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature